경조직 대치물에 대한 생체골 반응의 전자현미경적 연구
ELECTRON MICROSCOPIC STUDY OF INTERFACE REACTION BETWEEN HOST BONE AND HARD TISSUE REPLACEMENT(HTR)
최효영, 심광섭, 유광희,
소속 상세정보
최효영 ( Choi Hyo-Young ) - Hanyang University College of Medicine Department of Dentistry
심광섭 ( Shim Kwang-Sub ) - Hanyang University College of Medicine Department of Dentistry
유광희 ( Yoo Kwang-Hee ) - Hanyang University College of Medicine Department of Dentistry
KMID : 0362819940140010021
Abstract
Hard Tissue Replacement (HTR) is a synthetic polymer, which has been used as a substitute material clinically in case of bone defects, alveolar ridge augmentation and alveolar ridge maintenance. This experimental study was designed for evaluation of implanted HTR's biocompatibility to the host bone. HTR was implanted in the parietal bones and femurs of twenty-two rabbits. At an every interval of 4 days, 1 week 2, 4 and 8 weeks, four rabbits were killed, and the parietal bone and femurs where HTR had been implanted were decalcified for histological examination and transmitted to electron microscopy. At 4 days after implantation, a thin granular membranous structure surrounded HTR implant. A few inflammatory cells were intermingled with macrophages. An organizing hematoma lay on the inner surface of bone defect. At one week to 2 weeks, the capsule became a granulation tissue characterized by admixture of macrophages, fibroblasts and inflammatory cells. At 4 weeks to 8 weeks after implantation, the capsule turned out to be a scar tissue composed of abundant collagens with few cellular components. The results suggested that HTR was compatible with host bone tissue, although minimal inflammatory reaction and thin fibrous capsule formation around HTR were present.
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